2002 South American incident

In 2002, somewhere in South America, Leon S. Kennedy and his partner Jack Krauser are searching for Javier Hidalgo, an ex-drug lord who had been reported to be approaching Umbrella Inc. However, when Leon and Krauser reach the nearby village, they discover that the people there have been turned into zombies. Some zombies have the Sacred Snakes indentation, meaning that they worked alongside Javier. Leon and Krauser find their guide who, before he dies and has his body taken away by a water-bound BOW, says that the girl (Manuela) "brought devils to this village." Fighting their way past more BOWs and hungry piranhas, Leon and Krauser eventually find the girl, but have to face the creature that took their village guide. They successfully chase it off after Leon shoots the bell tower which causes it to fall on the creature. Krauser asks Leon to tell him everything about how he first encountered the BOWs. The scenario resumes after "Memories of a Lost City".

Due to rising water levels, the survivors make their way to the water dam, where Javier and his BOWs await. Javier releases the monsters to attack Leon and Krauser while attempting to retrieve Manuela. It is revealed by Javier that Manuela is his daughter and that he had been tampering with the T-Veronica virus. Leon tells Krauser the "Game of Oblivion" incident to give him the knowledge of the virus. Both of them also discover that Manuela has been receiving regular doses of the T-Veronica virus to contain her illness. At this point, Krauser finally pledges to Leon that he will view Leon as a worthy partner. Soon after, they learn that the reason Javier has been kidnapping young girls is because he was trying to extract organs to perform transplants in order to cure Manuela. Almost immediately, they are confronted by the gigantic monster that ambushed them back at the church, who they soon learn is actually Manuela's mother. Having the same illness as Manuela, she mutated due to the failure to keep the virus in check. Right before dying, she shoots out spikes from her body, one of which pierces into the arm of Krauser, wounding him. After defeating Manuela's mother, Javier injects himself with the T-Veronica virus. He begins to mutate and attacks Leon and the injured Krauser. Manuela assists Leon and Krauser in the battle against her father by using T-Veronica, at the risk of turning into a monster herself. The three survive, and are rescued by helicopter. The US government takes care of Manuela, and Leon and Krauser's story continues in Resident Evil 4.