Resident Evil: Resistance/gameplay

The game is a team-based cooperative game, with sessions consisting of a maximum of five players. Four players are "Survivors", who are given tasks to complete while being attacked by monsters. The fifth is a "Mastermind", who can manipulate the facility, watch the others via CCTV and send mutants to fight them. The Survivors can obtain "Umbrella Credits" during the course of each stage, which is used to purchase recovery items or new weapons. The Mastermind on the other hand depends on a point system which is used to spawn new creatures, traps, or arm the CCTV camera with a machine gun.

The Survivors must work together in order to escape the Umbrella facility within a given time limit. When a survivor takes too much damage, they get in a downed stated, and a team mate can revive them if they get there in time. If they don't get any help, the player will respawn elsewhere but a chunk of time will be lost with each death. Each survivor has their own set of skills and a label that defines them as "Damage", "Hacker", "Support" and "Tank". Weapons picked by the survivors consist of not just firearms but melee weapons like 2x4s or a Steel Bat.

As the Mastermind, the player must watch the survivors via Security Cameras and prevent them from escaping, impeding their progress by locking mechanical doors, placing traps, or summoning creatures and even controlling them. Known enemies in the game include Zombies, Lickers, Zombie Dogs, Ivy and a T-103 Tyrant.

It was confirmed during the presentation at TGS 2019 that the game will include a single-player campaign.