Blob

A Guardian of Insanity is a creature originating from human prisoners trapped below the Spencer Estate. After being infected with an unidentified virus, they became the "guards" of the underground.

Physiology
Physically, its body shows signs of decay, not unlike that of Zombies. Furthermore, its face appears to have dissolved into boils, and its back has increased size from muscle growth to the extent of needing a harness. This growth also has a yellow eye as seen from behind, similar to G, which serves as a weak point.

It appears to possess superior strength, based on the fact that its anchor is far larger than itself, and its ability to lift its enemies off the ground single handed. It also seems to have heightened senses, the second guardian encountered by Chris Redfield and Jill Valentine able to deduce that they were directly behind a breakable wall.

Attacks
The Guardian of Insanity's attack are very similar to those of the Executioner.


 * Slam - The guardian slams its anchor on the player, taking them into dying status.
 * Swing - The effects of this attack is similar to the "slam".
 * Acid Blood - When the massive growth on its back is shot, it will release a stream of acid, stunning players who are near and doing minor damage.
 * Grab - The Guardian will grab the player off the ground. There is no dodging prompt for this attack. If grabbed the player has a small time frame of rescue. If not reached, the Guardian will thrust its anchor in an upward motion, impaling the player and resulting in instant death.

Strategy
The guardian is unable to run, making them quite easy to escape from. The small eye located on the back of the large tumour is the best weak point. When shot or stabbed, the eye will bleed violently and 'spin'. If you keep shooting the eye, the Guardian will easily die. (On Easier modes one shot from a magnum will kill the Guardian if shot in the eye). The large tumour growth on its shoulder is another weak point, where several hits from a shotgun will kill or severely injure the creature. Melee weapons such as Combat Knives are ineffective as the Guardian will spray acidic blood when injured, however it is possible to "knife" the Guardian. Continuous damage to the head, or the tumour on the shoulder can take a Guardian down to its knees, leaving it vulnerable to the follow melee attacks; Jill: Sweep Kick / High Kick Chris: Uppercut / Straight.

During their search of the Spencer Estate for Ozwell E. Spencer, Chris and Jill resorted to using booby traps against the Guardians. These spiked platforms would drop from above like a moving ceiling, crushing and impaling any creature caught beneath them, though the Guardians may be able to stop the platform from crushing the sometime by using their anchor, at that time the player can either melle them or throw a flash grenade to stop and kill them; Jill: Flip Kick Chris: Haymaker.

Trivia

 * This enemy's fighting style and motions seem to be taken from the Executioner Majini in the original Resident Evil 5.


 * Due to certain mutations and deformities present on the Guardian, it appears that he may be infected with some strain of the G-virus.
 * The guardian is the only enemy in RE5 who does not have a figure avaliable in the bonus features.
 * Bears a few resemblances to Lisa Trevor from RE Remake.


 * A maximum of eleven Guardians can appear on Veteran mode
 * two in the Mansion - as documented here
 * five in the Basement
 * four in the Sewers

In easier difficulties, the number of Guardians drops down significantly to as low as five.
 * For the four in the sewers it is possible to kill them with a knife instead of the spiked platforms.
 * In the prison block, a Guardian passes Chris and Jill from a platform above. If you can stun him at this time with Incendiary Grenades, you can reach the top floor before he escapes and defeat him; he counts as a secret Guardian.
 * The higher the difficulty you play on, the faster the Guardian's attacks will be. The "slam" attack will be insanely fast, while the "swing" attack can move so quickly, it is almost impossible to dodge. It is recommended that one should run past the Guardian after landing a second melee attack, as trying to turn around and run will almost always result in getting mauled. The grab motion will also increase in speed to where it is impossible to dodge if the animation starts up. The Guardian's attacks move at their quickest on Professional mode.
 * The Guardian of Insanity can be compared to the Executioner (Red). Both have a weak point on their back (Eye, Plaga Spot)