Dominant species Plaga

A Master Plaga is a Las Plagas parasite of the equivalent of a King. Plaga and Plaga-controlled organisms will generally respond to the "Kings"'s wishes, whose orders are projected via projections through a staff.

The only known Master Plaga seen was the plaga inside Los Illuminados leader; Osmund Saddler.

Ada Wong and Jack Krauser were sent on a mission to find a sample of a master Plaga by Albert Wesker for his own personal knowledge again. Ada retrieved the sample but did not give it to Wesker. She instead gave it to the the Agency, the organization she was really working for. Although Wesker never obtained a master plaga sample, he did manage to obtain regular plaga and control plaga samples soon after Las Plagas began to appear in the black market.