Resident Evil 6/plot

The game takes place over a period of at least six months from December 2012 to June 2013, over fifteen years after the US Government's destruction of Raccoon City, and takes place in various places around the world.

Leon's campaign
June 23, 2013

In United States - the President is about to "come clean" over the incident in Raccoon City in a seminar at Ivy University, Tall Oaks, when he himself mutates into a zombie. A man at the university guides Leon S. Kennedy and his partner, Helena Harper, through the campus in the search for his missing daughter, Liz. During the search he started coughing and begins to make suspicious complaints of skin irritation. They eventually find his daughter, only for her to turn into a zombie and eat her father in an elevator before turning on Leon. After they break out the elevator, they fight through a parking lot and into a surveillance room. Following on from there, the partners fight their way through the University to a police car and attempt to drive off, only to be flipped causing them to use the manhole nearby.

This led the pair through the train lines and into the center of Tall Oaks to find the entire city infected. Fighting through the streets, they make it to a gun store where they meet up with other survivors: a couple and a police officer. After Leon and Helena fight off the intense horde in the gun shop, they are allowed upstairs by the gun store owner, only to be assaulted by a greater amount of zombies. Eventually a school bus meant to bring the survivors to safety arrives, and the survivors escape except for the gun store owner who is dragged out the window of the bus and the japanese tourist who try to save him but fail.

During the incident in the city, Leon is informed by Hunnigan that the city has been overrun, and that about 70,000 people are expected to have become infected.

Chapter 2 begins on the bus as they drive through heavy rain to reach the cathedral. The driver attempts to run over a zombie but this sends the bus teetering off a cliff. As all the survivors are killed grusomely by a nearby horde, the bus falls off the cliff leaving Leon and Helena as the sole survivors. Making their way through a cementary and eventually the font door of the cathedral, they are stopped by a man inside the cathedral who starts ringing the church bells. After survivng the incoming attack they are let into the cathedral, but Helena finds that the passage way is not open yet. After searching the cathedral and solving various puzzles, the passage opens but a Lepotitsa emerges. Infecting survivors with its gas, Leon and Helena kill the abomination and enter the underground facility. Helena finds what she was looking for, her sister Deborah Harper Leon also finds a video labelled "Happy Birthday Ada Wong ", which depicts a confusing birth of a woman who looks like Ada. Deborah turns out to be infected with the C-virus and turns into a Chrysalid, and then into a blank woman with large claws sprounting out her back. Ada also turns up to help with the fight.

After Deborah is killed, Leon and Helena escape through the catacombs and are attacked by a shark-like monsters. After going down a large waterslide they eventually kill it with an explosive barrel. As they drop out from the tunnel, they witness the nuclear sterilizing of Tall Oaks, just like Raccoon City. Hunnigan informs Leon that Derek C. Simmons just left the Agency in a hurry and is headed for China. Leon asks Hunningan to fake his and Helena's death. After he states that they're going to China.

Jake's Campaign
December 24, 2012

Jake Muller, a mercenary of the fictional South-Slavic Edonian Liberation Army flees from the authorities during a bio-terrorist attack. There he partners up with Division of Security Operations (DSO) agent and Raccoon City survivor Sherry Birkin, who needs Jake because of his rare antibodies that could lead to an antidote for the C-Virus. Jake agrees, but only if he recieves $50 million in return. Sherry and Jake's extraction from Edonia by the B.S.A.A. is sabotaged by a B.O.W. codenamed 'Ustanak', forcing the pair to crash into the mountains, there we find out that due to the G-Virus that is still dormant in Sherry's system, Sherry now has a regenerative healing ability. After making it to the other side of the mountains, both Jake and Sherry are captured by Neo-Umbrella, where "Ada Wong" tells Jake his real father was bio-terrorist Albert Wesker. For the next six months both Jake and Sherry are subjected to numerous tests by the bio-terrorist group.

June 30, 2013

Jake and Sherry manage to break out of the Neo-Umbrella facility, only to find themselves in Langshiang, China. Sherry manages to get in contact with her superiors and sets up a rendezvous in China. On the way over to the rendevous, they both witness a U.S. Government plane crash into the city, where they find the two survivors of the crash, DSO agent Leon S. Kennedy and U.S. Secret Service Agent Helena Harper. There they find out that Sherry's boss, Derek C.Simmons, is the one behind the C-Virus bioterrorist attack. Sherry informs Leon that she is actually supposed to meet up with Simmons in Lanshiang. Before they can finish their conversation they are attacked by the Ustanak and once defeated, the two pairs agree to meet up at the rendevous point.

When Jake and Sherry finally arrive at the meet-up location, they find Leon and Helena in a face-off against Simmons, who readily admits that he is the one behind the outbreak and explains that he did it in order to maintain both U.S. and global stability. Simmons then proceeds to order his guards to shoot down Leon and Helena. While in cover, Leon asks Jake and Sherry to escape while they settle their personal score with Simmons. They leave, but not before Sherry hands Leon an SD card containing vital research information regarding Jake's antibodies. Jake and Sherry manage to escape, but are captured once again by Neo-Umbrella.

July 1, 2013

Jake and Sherry find themselves trapped in Neo-Umbrella's underwater facility at the bottom of the ocean. Thanks to a tip from Leon, B.S.A.A. agents Chris Redfield and Piers Nivans manage to find the underwater facility and free Jake and Sherry. Before they escape, Chris tells Jake that he not only knew his father, but he is also the one that killed him. Jake, now taken over by his emotions, reflexively pulls out his gun and proceeds to fire a one-off shot at Chris, just barely grazing Chris' face. Before the situation could get anymore intense a massive B.O.W., Haos, awakens from his coccoon. Knowing how vital Jake's blood is, Chris tells Jake and Sherry to escape while him and Piers take on the creature. When trying to escape from the facility, the Ustanak shows up again for a final confrontation with Jake and Sherry. After finally putting down the Ustanak, they are able to escape from the facility.

Epilogue

Some time later, Jake hands over Sherry a sample of his blood and disappears—though dropping his price down to only $50. The B.S.A.A. agrees to keep Jake's identity top secret, to insure that nobody comes after him. Thanks to Jake's blood a vaccine for the C-Virus has been distilled, and the outbreak is gradually contained. In the Secret Ending (which is obtained by defeating Ada's campaign) we see that Jake continues the fight against the B.O.W.'s in an underdeveloped country(Somewhere in the Middlie East).

Chris' campaign
After the deaths of a number of soldiers under Chris' command at least six months prior in Edonia (The actual date being December 24, 2012) Chris left the B.S.A.A. and became a drunken wreck, before being convinced by Piers Nivans to come back and finish his mission to end bioterrorism, Chris reluctantly returns to the organization.

Chris Redfield and the B.S.A.A. - including Piers - are soon after sent into a war-torn China, around the coastal Chinese city of Lanshiang.

Ada's Campaign
Ada's campaign is unlocked following the completion of the 3 main campaigns and is the only campaign to feature solo play. In Ada's story, it is revealed that the Ada Wong that interacted with Chris Redfield and Piers Nivans was actually a Doppelgänger, a scientist named Carla Radames, and that the real Ada Wong was aiding Leon S. Kennedy and Sherry Birkin while destroying the Neo-Umbrella lab in Lanshiang. Although presumed dead, Carla tries one last attack against the real Ada, after having injected herself with a powerful dose of the C-Virus, but is killed. As Leon and Helena battle with Derek Simmons, Ada reaches the lab where her clone was developed and destroys everything. She then receives a call from someone, accepting a new assignment. Unlike the other 3 campaigns, Ada doesn't get an after credits epilogue like the others, but instead unlocks a Secret Ending.