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The Guardian of Insanity is a powerful monster that appears in the Lost in Nightmares DLC for Resident Evil 5.

Description
Little is known about the Guardians of Insanity, apart from the fact that they were scattered throughout the Spencer Estate circa 2005, apparently serving as the mansion's protectors. The creatures use a large anchor as a weapon. Physically, its body shows signs of decay, not unlike Zombies. Furthermore, its face appears to be dissolved into boils, and its back has increased size from muscle growth to the extent of needing a harness. This growth also has a yellow eye as seen from behind, which serves as a weak point. It appears to possess superior strength, based on the fact that the anchor is far larger than itself, and it can lift its enemies off the ground with one hand. It also seems to have very good hearing or smell  as one  point when it smashes through the  wall meaning it was able to detect the player   somehow.

Attacks
The Guardian of Insanity’s attack are very similar to those of the Executioner.
 * Anchor Slam - Takes the player into dying status.
 * Anchor Swing - Same as Axe Slam, except if he catches both of you it will result in instant death.
 * Acid Blood - When the massive growth on its back is shot, it will release a stream of acid, stunning the player and doing minor damage.
 * Grab - The Guardian will grab the player off the ground. There is no dodging prompt for this attack. If grabbed the player has a small timeframe of rescue. If not reached, the Guardian will thrust it’s anchor in an upward motion, impaling the player, resulting in instant death.

Game Appearance
The Guardian appears in the Lost in Nightmares episode, in the basement of the Spencer Estate. However, under the right conditions, it is in fact possible to fight one inside the mansion itself, as seen here

Famitsu online translation reveals that an alternative translation for this new enemy is "The Keeper of Madness". The keeper will follow the player around the mansion's basement. Biohaze has revealed that there will be multiple Keepers. In order to finish the third chapter, the player will need to kill four of these. During this battle, the player has no weapons except a knife and a few obtainable flash grenades. The aim is to lure the Guardians into crank-activated spike traps, that can be used to crush them.

Strategy
It uses the same model as the original Executioner. However, due to the Guardian's extra attacks, he is a much more formidable opponent. When fought one at a time, they are much easier to take down, but fighting two at once will almost always result in death or serious injury to the player.

Knifing will be extremely ineffective, as the Guardian's acidic blood will damage the player at close range. Continuous shots to the head, or the cyst-like growth on his shoulder will take him down to his knees, where he can be attacked with a melee move.

In the third sub-chapter, 4 of the Guardians are fought, two appearing at one time. During this battle, the player is stripped of weapons except their knife. There are a few flash grenades to be found, but no firearms whatsoever. This fight requires spike traps to be set by one character, whilst the other lures a Guardian beneath it. Once the player is out of the way, they can deploy the trap, which will kill it.

Some of the Guardians may withstand the intitial impact of the trap, and hold it up using their anchor. A simple flash grenade can stun them enough to allow the trap to collapse on top of them.

When in this area, it is best to avoid the Guardians as much as possible, until you have aquired all the cranks neccessary for the traps, and a few flash grenades for any enemy that withstands one. If too close too a Guardian, they will begin chase on you, yet if the player succeeds in running far enough way, it will lose you and return to it's original patrolling area.b

Guardians are cunning enough with there attacks may surpise the player at certain points. In one example on veteran one guardian is cunning enough to wait on the corner of the stairwell on the prison area then slam his hammer down it also seems that they have high hearing or smell as one guardian was able to hear the player behind a breakable wall.

Trivia

 * This enemy vaguely resembles Lisa Trevor; an unlikely reference to her involvement with Spencer at the first Spencer Estate.
 * This enemy's fighting style and motions seem to be taken from the Executioner Majini in the original Resident Evil 5.
 * It appears as though it was infected by the G-virus due to the eye on its right shoulder.
 * A maximum of 10 Guardians can appear on Veteran; 2 in the Mansion, 4 in the Basement, and 4 in the Sewers.