Queen Plaga

Not much is known about this giant plant as it is seen once, it might have been a tribute to the resident evil 1 plant 42 boss as they are greatly similar in appearance. The plant is seen when you fight Ramon Salazar in chapter 4-4. When, at that point Salazar was having a ritual. In the cutscene this plant looks like a closed rose, then Salazar has the plant combine Salazar and Verdugo with the plant itself; this then creates the Salazar boss.When combined this plant has quite a few weak points (its eye and Salazar, himself).

Strategy
You should buy a weapon with massive damage such as a killer 7 and a rocket launcher (save rocket). In 1 or 2 hits to the eye (with the killer 7) it will reveal its weak point (Salazar), here use your rocket launcher as it will be fast and easy. Salazar will die and the plant will dissolve.