Alexander Isaacs (clone)

Dr. Sam Isaacs Was an Umbrella Corporation scientist, in charge of the Nemesis Program. He is portrayed by Iain Glen. He greatly disliked his immediate superior, Major Timothy Cain, a feeling that Cain returned.

Raccoon City Outbreak
Immediately following the disaster in The Hive, it was Isaacs, who, at Cain's direction, experimented on Alice and Matt Addison. But disaster struck when Cain unwisely chose to re-open the Hive, despite the containment procedures. Zombies and Lickers escaped the facility, and the T-Virus overran Raccoon City, with Alice and Addison, now subjects in the Nemesis program, still inside.

Following the bombing of Raccoon City, Isaacs was dismayed to learn that both Alice and Addison were dead. But he was able to recover Alice's body from the wreckage of the helicopter she used to escape, and moved her and his work to an Umbrella facility in Detroit. After three weeks of experiments, Alice was revived with incredible new powers. Unfortunately, she retained her memories and escaped, being rescued by Jill Valentine, Carlos Oliveira, and Lloyd Jefferson Wayne. But Isaacs had one lastr trick up his sleeve, and as Alice makes her escape, he mentions that "Program: Alice" has been activated.

Worldwide Infection
Umbrella soon had bigger problems than one escaped experiment, however. It was soon discovered that the T-Virus had escaped Raccoon City, and began spreading rapidly. The world was overrun in short order, the only survivors being the civlians who stayed on the road, and Umbrella Corporation employees, who took shelter in underground facilities across the planet. Isaacs himself took charge of the research in an underground lab in the Nevada desert, trying vainly to track Alice across the wasteland that North America had become over the last five years. All the while, he maintained a combative relationship with Umbrella Chairman Albert Wesker.

Isaacs, who had begun a cloning program to recreate Alice, attempted to use the clones' blood to "domesticate" the zombies, making them tame enough to allow humans to return to the surface. This was possible because, as he discovered, while the zombies hungered for human flesh, they derived no actual sustenance from it, and could remain active for decades or more. The results did succeed in raising the intelligence of the test subjects, but resulted in a stronger infection.

Finally realizing that only the real Alice could bring him success, Isaacs falsified orders from Wesker and took a strike team into the wastes to deactivate and retrieve her. He made camp in the ruins of Las Vegas, setting a trap with the enhanced zombies to kill her so they could retrive her corpse.

Mutation and End
The scheme did not go as he had planned. Alice massacred the strike team, and Isaacs was bitten by an enhanced zombie. He returned to the lab and was placed under house arrest. He injected himself with large quantities of the Anti-virus, but his condition continued to deteriorate.

Wesker, meanwhile, had had enough. He ordered Isaacs' immediate termination. An executive at the facility carried out the order, shooting the scientist in the cheast and leaving him for dead. It was too late. Isaacs had already begun to mutate, tranforming into a grotesque, tentacled monster who then proceeded to slaughter everyone in the facility. Taking action, the facility's AI, the White Queen sealed him in the lower levels.

Some time later, Alice entered the facility, and, after consulting with the White Queen, descended into the lower levels to kill Isaacs. The fought in a replica of the Specer Mansion, their fight eventually moving into the reconstructed "Laser Room."

Isaacs taunted Alice, telling her that "I am the future." Alice responded that he is, "Just another asshole," and that they are both going to die down there. As Isaacs moveed in for the kill, the laser grid activated, controlled by a newly-awakened clone, and cut him to bits, putting an end to the deranged scientist once and for all.