Axe Man

The Axe Man was the murderous alter-ego of Albert Lester, created after the closure of the Abandoned Hospital, when Albert was infected with the T-Virus. He would lure travelers to the hospital and murder them with his axe, feeding them to the plant which he thought of as his late wife, Dorothy Lester.

As an Enemy
During the Flashback scenario of Resident Evil: Outbreak File 2, the Axeman follows the player character around. Although he cannot be killed, he can be driven away temporarily after enough damage has been dealt.