Leon Scott Kennedy/gameplay

Resident Evil 6 (Campaign)
Leon's section in Resident Evil 6 story mode is heavily focused on the survival horror genre, just like the early Resident Evil games. In most parts of his segment, the player must advance slowly over dark and claustrophobic places with an intense horror atmosphere. His scenario also marks the return of classic enemies such as the Zombies. Leon's unique ability is the dual wielding - making him the only character able to use two weapons at the same time. His primary weapons is a pair of H&K VP70 and a Survival Knife. Leon's partner during his scenario is Helena Harper.

Much like the other characters in the game, Leon also has some contextual-based action attacks, a melee system used in Resident Evil 4 and Resident Evil 5.
 * Roundhouse Kick - A common attack, Leon gives a swift roundhouse kick to a stunned enemy that sends them back, as well as any enemy nearby. This is most commonly performed on a lightly stunned enemy from any direction.
 * Armlock Throw - Leon grabs the enemy's arm and pushes him while he ducks, throwing the enemy to the ground. This is most commonly performed on a heavily stunned enemy from the front.
 * Bulldog - From behind an enemy, Leon jumps at the enemy's back and falls, using his body weight to smash the enemy's face to the ground. This is most commonly performed on a heavily stunned enemy from behind.
 * Kick - Leon kicks an enemy away from a partner being grabbed. This is only performed as a prompt to rescue your partner as they are being attacked.
 * Stomp - A common attack, Leon uses his foot to stomp on a grounded enemy. If performed near the enemy's head, it has a chance of crushing it. This can only be performed against a grounded enemy.
 * Stab - Like Chris' attack, Leon wields his knife in both hands and stabs it into a fallen enemy. This can only be performed against a grounded enemy with the Survival Knife equipped.
 * Shoulder Rush - A simple counter attack, Leon charges into an attacking enemy with his shoulder to throw them back. This is performed as a counter-attack to an unarmed zombie attempting to grab the player.
 * Pipe Bash - A counter attack, Leon grabs the weapon arm of an attacking zombie and shoves them away as he takes the pipe from them, then uses it to cave in the enemy's head. This is performed as a counter-attack to a zombie attacking with an melee weapon such as an iron pipe or axe.
 * Head Stab - With a conveniently placed knife, Leon removes it from the zombie's body and re-buries it into their head from under their chin. This is performed as a contextual attack against a zombie that has a knife already embedded in their body and typically replaces any other contextual.
 * Wall Smash - Leon will grab the stunned enemy by their head and promptly smash it into the nearby wall. This attack can only be performed when an enemy is stunned next to a wall and will usually replace any other contextual action.

Resident Evil Deck Building Game
Leon is a character in the base set of the Resident Evil DBG. He specializes in handguns, and his abilities are appropriately similar to Krauser's. Leon's level one effect allows him to decrease the amount of ammo needed to use handgun type weapons. His Level 2 effect allows him to use any handgun he has twice, easily doubling whatever damage he was set to deal to a target. In addition, weapons that have effects that can only be triggered following an Explore action can also have their effects used twice. The Silver Ghost and the Punisher for example, can be easily exploited in this manner.

A second Leon character card has been revealed for the expansion set Alliance. and seems to be based on the Darkside Chronicles rendition of his Resident Evil 2 self. This Leon card does not specialize in handguns, or any weapon for that matter. His Level 1 effect allows the player to move one card from his or her Discard Pile to the bottom of their Inventory. To aid this, his Level 2 effect allows the player to move the card at the bottom of their Inventory to the top, ensuring that they will draw the designated card next turn or through another card's effect. Both of the above Leon cards have 80 Health.

A third Leon card was added in the third expansion set Outbreak, is based on his RE4 appearance, and has new abilities. His Level 1 ability allows the player to put a card from their Hand on top of their Inventory during their turn. This has uses such as saving the Rocket Launcher from the Base set (if owned) until you predict a powerful card, such as Albert Wesker from the first expansion set Alliance. His Level 2 effect state that during a player's turn, they can exchange card in their Hand for an Action card in their Discard Pile. This version of Leon has 70 Health.

A fourth Leon card is one of the ten characters in the Nightmare set. He mimics the effect of the Parting Ways action card, by allowing the player to Trash a card from their hand to gain one worth up to 20 Gold more.