San Francisco, California

San Francisco was a city in the state of California, widely (and incorrectly) believed to be the origin point for the Global T-Virus Outbreak. In reality, the infection began with Raccoon City infectee Jim Knable. During the crisis, the state governer gave executive authority to the Umbrella Corporation scientist Jaime Cerota, who tried and failed to contain the virus in the Mission District. The city was overwhelmed, with all of Earth not far behind.