Colt Python

The Python was Colt's premier revolver, production starting in 1955 and ending in the nineties. It is known for superb accuracy and slick function and was very popular in both the cinema and for issue amongst law enforcement. Today, they are coveted for their beautiful aesthetics as well as superb function, a fitting weapon for a gun-savvy character like Barry Burton.

In Resident Evil
Like all magnums appearing in the Resident Evil series, the Colt Python is very powerful, often killing regular enemies in a single hit, but has an exceedingly limited supply of ammunition and should generally be saved for boss battles.

Resident Evil
The Colt Python is a .357 Magnum revolver appearing in ''Resident Evil. ''It is Barry Burton's primary weapon throughout the game. Players can obtain the python by inserted two gems into the eyes of a statue within the mansion. One gem is found in place of the eye of a stuffed deer head in a room in the manion, while the other gem is found by pushing a statue off of the second floor of the dining room. When both gems are inserted into the Tiger head statue, it will rotate, revealing the Python.

Code Veronica
The Python is also available in  Resident Evil Code: Veronica. To obtain it, players must refill the fire extinguisher by using a machine within the Antarctic Base. The fire extinguisher must then be used to put out a fire in order to obtain the magnum.

Resident Evil (REmake)
In Resident Evil's remake, the Colt Python is demoted from Barry's main weapon to a weapon that is found inside the Mansion, while Barry's revolver is switched to the Colt Anaconda. The Python found in the Remake is known as the Elite Python, an Umbrella produced variant.

Revelations

The Colt Python is found in Resident Evil: Revelations under the name Magnum Python.

Comparison to the Silver Serpent
The Silver Serpent replaced the Colt Python as Barry's main weapon in the RE1 Remake. It is essentially the same weapon, but with a large muzzle weight running the length of the barrel, and having a dull silver finish, as well as being chambered for the more powerful .44 Magnum round. The Colt Python can still be found in the game after an optional puzzle with three medallions and a tombstone.

Interestingly enough, the Python externally is identical to the Silver Serpent, with the same recoil-absorbing barrel weight and custom grip. This makes little sense, as one is supposedly produced by Umbrella, and the other hand-built by Barry. It can be assumed this was done to cut down on the work load for two functionally similar weapons in-game.