Alligator/gameplay

Resident Evil 2
The Alligator can be defeated in Scenario A by simply shooting it (though the monster is really tough), causing it to eventually smash a hole in the wall and escape. A small amount of ammo will appear a little later on. If the Alligator is defeated this way in Scenario A, it will come back again in Scenario B. In this Scenario, shooting the monster until it collapses will finally kill the creature for good.

The other more economical method involves releasing an emergency gas canister which the Alligator promptly picks up in its mouth. When the canister is shot, it explodes, taking much of the Alligator's head with it. Defeating it this way means it can be killed with only one handgun round. Also if the monster is killed this way in Scenario A, it will no longer come back in Scenario B.

Resident Evil Outbreak File 2
In Outbreak File #2, the only strategy is to just swim over the area where it lives. If you really need to shoot it, stay on the dry land but close to the water. Alligator eventually will swim to the edge and try to attack you on land. When it tries, just shoot it. It will take quite a few shells from the shotgun to take it down, but using the Hunting Rifle will kill it in two shots.