Rejected content from Resident Evil 5

Elements of the Resident Evil 5 story plot changed over the course of its four year development.

Jill Valentine
At one point in the development, Chris Redfield and Sheva Alomar were supposed to find Jill Valentine in her capsule in the Tricell facility. This was rejected in favour of having Jill serve Albert Wesker as a brainwashed puppet.

Excella Gionne
Excella was, at one point, intended to be killed by a Tyrant, which would impale her chest á la Resident Evil.

Ending
As can be seen in the below panels, one of the ideas for the game ending was to have Chris and Sheva commandeer an aircraft and fire missiles at Wesker.