Angela Ashford

I'm not a little girl. Besides... all my friends call me Angie.

Angela "Angie" Ashford was the only child of Doctor Charles Ashford, the inventor of the t-virus. Because Angela possessed the same degenerative nerve condition as her beloved father, Angela was destined to eventually spend the remainder of her life in a wheelchair. Her father prevented this by developing the t-virus. While in almost all cases of humans infected with the virus suffering uncontrollable mutation, the reproduction of dead cells that the t-virus caused was enough to allow Angela to regenerate her limbs and walk again (if kept in check with injections of an anti-virus).

Raccoon City Incident
When the t-virus escaped The Hive and broke out amongst the population of Raccoon City, Angela, due to her father's high-ranking position within Umbrella, was among the employee family members chosen for evacuation. To this end, Angela was immediately pulled out of her class at school by Umbrella security personnel and attempted to get her out of the city before the infection spread too far. The Umbrella SUV that she was in, however, crashed (due to a truck driven by the newly-zombified driver) and it's occupants save for Angela; killed, and as such Angela was trapped within the city.

Charles was forced to find another way to retrieve her from the city before all evidence of the outbreak was destroyed via. nuclear weapon. Charles, using her personal locator, tracked Angela down to her junior high school, where Angela remained in hiding. To get her out, Charles found and contacted several survivor groups, including Ex-Umbrella Security Operative Alice Abernathy, former-S.T.A.R.S officer Jill Valentine along with S.T.A.R.S Sergeant Peyton Wells, Disgraced-Raccoon 7 News Reporter Terri Morales, Small-Time Thug Lloyd Jefferson Wayne and Umbrella Biohazard Countermeasure Force commandos Carlos Oliveira and Nicholai Ginovaef. After explaining that Umbrella will detonate a nuclear device on Raccoon at sunrise, covering up the infection and killing all witnesses caught in the blast, made a deal; Charles would arrange for them to escape, but only if they would retrieve Angela and bring her to him safely.

Angela was indeed saved, and was reunited with her father, but only for a few moments before he is shot and killed by Major Timothy Cain. Angela, along with Alice, Jill, Carlos and L.J.. escaped Raccoon on an Umbrella helicopter transport, mere seconds before it was nuked. Alice was killed when she was impaled by a metal pipe broken off the out-of-control helicopter, taking the blow meant for Angela. After surviving the crash, Angela could sense, with her T-Virus abilities, that some part of Alice still lived. As such, despite the growing manhunt for Jill and Carlos, they were able to arrange to free the-now-revived Alice from Umbrella's Detroit facility, with Jill, Carlos and L.J. posing as Covert Umbrella Operatives taking her into custody. Angela asked Alice if she was alright, but Alice ignored her completely, the cybernetic conditioning in her mind activating as they drove away.

Death
After escaping from Raccoon City in 2002, Angela and her new friends remained in hiding for some time from Umbrella and U.S. Government agents secretly under their employ. Eventually, the Global T-virus Outbreak began and Angela, Alice and the others joined up with other survivors into The Strike Team, a mismatched collection of survivors journeying across the United States saving as many people as they could from the growing zombie legions. It was during combat with zombies besieging yet another survivor enclave that Samuel J. Isaacs tested his cybernetic control over Alice, implanted via a chip in her brain during her time in the Umbrella facility. Isaacs commanded Alice to return to Detroit (one of the few cities protected from zombies and mass upheavel), and bring Angela with her (at Chairman Albert Wesker's behest). Upon their arrival, however, Isaacs explained that Angela was of no use to Umbrella's research in finding a permanent T-virus cure, as the strain of T-virus she had within her was an entirely different strain from the one sweeping across the globe. As such Isaacs ordered Alice to kill Angela, which she did so by shooting her in the head, killing her instantly.

Trivia

 * Angela only appears in the live action continuity. She is portrayed by Sophie Vavasseur.
 * Angela's character was neither seen nor mentioned in the third film. Her fate is only revealed in the novelization of Extinction.
 * Angela's role as a "young child of an Umbrella scientist known to have developed the T-virus" is similar to the back-story of Sherry Birkin in the game Resident Evil 2.