El Gigante

El Gigante(literally the giant, in Spanish) is one of the recurring bosses in Resident Evil 4. You can fight it a total of 4 times. They have a wide variety of attacks, including a running charge involving action buttons, and a grab and choke. A good strategy is to run either around it or through its legs and pump it full of lead when it's coming towards you. When you have shot it enough, it will expose its Los Plagos. When that happens, you will either have to shoot the Los Plagos or jump on top of it and slice it.