Paul W.S. Anderson film series

The live action Resident Evil came out in the 21st century and contain references to the games, whilst establishing their own canon.

Films

 * Resident Evil - (Also known as Resident Evil: Genesis).
 * Resident Evil: Apocalypse
 * Resident Evil: Extinction
 * Resident Evil: Afterlife

Storyline
In 2002, an underground Umbrella facility underneath Raccoon City, "The Hive", experiences a viral outbreak afer the T-Virus is intentionally released during a theft. The facility's AI, the "Red Queen", attempts to stop the outbreak from spreading outside by killing the research staff. Later that day, an Umbrella special forces unit brakes into the facility's secondary entrance, a mansion in the mountains, to investigate the lack of communication with the Red Queen. They bring with them three people they find - Alice, the lab's security officer; Spence Parks, her husband and co-worker, and Matt Addison, a police officer investigating the area.

Entering the area, they find the facility empty of the research staff and proceed to shut down the AI, loosing four of their team in the process. Little did they know that the AI was stopping the now zombified research staff from escaping. The team is attacked and infected during their escape. Eventually, only three people escape the facility, with one being euthenised along the way. Alice and Matt are taken away by Umbrella for experimentation.

While Alice is unconcious, the new Umbrella team proceeds back down to the lab and forces the sealed door open; they are quickly killed off by escaped B.O.W.s. Within a matter of hours, the city's roads are walled and its people are being slowly evacuated by Umbrella. After a zombie makes it to the gate, the gate is closed and the citizens are forced to fend for themselves.

Umbrella sends in the Umbrella Biohazard Countermeasure Force to surpress the outbreak, but they underestimate the combined strength of the zombies and B.O.W.s, and many of them are killed quickly. Elsewhere, a S.T.A.R.S. team is completely wiped out by Matt Addison, who has been converted into the "Nemesis" B.O.W.. Alice, waking up in an abandonded hospital, finds a group of survivors - Jill Valentine included - and, upon making contact with Dr. Charles Ashford, searches for his daughter Angela in order for him to give them a way out of the doomed city. Rescuing Angela, the group heads off to Raccoon City Hall, where the Umbrella paramilitary executive has based himself. Reaching the helicopter on the roof, Charles is executed by the commander. The survivors eventually make it to the helicopter and escape, leaving the commander to be eaten by a resurrected Charles. The city is destroyed after Umbrella launches a nuclear-tipped missile into city hall.

Alice is injured after the helicopter takes damage, and is left for dead after crashing. Umbrella claims her body and experiments on her with the T-Virus. She wakes up in another facility and escapes using newly-latent psionic powers. Meeting up with the other survivors, they make an attempt to spread word onto the world, who, due to Umbrella's influence, deny the evidence.

Meanwhile, a Raccoon survivor boards a plane to Los Angeles, and another to Tokyo. Both becomes zombies on arrival and the virus quickly spreads again. By 2007, five years after the Raccoon City incident, human civilisation has collapsed and the mere million-strong survivors are scattered across the world, always under the constant threat of the infected. Alice uses her psionic powers to defend herself as she makes her way to Las Vagas, where a convoy of survivors also heads off to - due to it being a hotspot for infected crows at one point, the zombies in the area have been wiped out. Alice meets the convoy leader, Claire Redfield, and the two make preparations for camp.

Elsewhere, Dr. Isaacs makes multiple clones of Alice based on DNA collected from her while she was being experimented on five years earlier. He uses their DNA, which was altered by the T-Virus, on a number of zombies in an attempt to cure them of the virus and return them to normality. The evolved zombies soon escape to Las Vegas, assaulting the convoy en-masse. Alice stumbles onto Isaacs' research facility and battles the monster that he has become. Afterwards, she learns of Albert Wesker, the Umbrella executive working in the shadows and targets him as her next victim.