Dorothy Lester

Dorothy Lester was a patient in the hospital located in the Arklay Mountains, and the wife of the hospital administrator, Al Lester. She was terminally ill, and was given drugs derived from the T-Virus by the Umbrella Corporation-owned shell company, Drugs Inc.

She was infected and became a zombie, killing the journalist Kurt and eventually being consumed by the infected plant in the hospital's basement. Her husband, by then an infected psychopath, eventually came to think of the plant itself as being Dorothy. Taking on the persona of the Axe Man, he would lure travelers to the hospital and murder them the feed "Dorothy."

When a group of survivors fleeing the T-Virus outbreak in nearby Raccoon City, one of whom was Kurt's friend Alyssa Ashcroft, came across the the hospital, they discovered the truth and killed the giant plant to escape, causing it to expel Dorothy's decomposing corpse. Her husband cradled the body as the hospital began to collapse, both being crushed by falling debris.