Barry's 44 Magnum

In Resident Evil
Replacing the Colt Python as Barry's weapon of choice in the Resident Evil remake, the Colt Anaconda is the larger cousin of the Python, with an identical design re-sized for the .44 Magnum round. The Anaconda is obtained only by Jill Valentine, and only if Barry is killed. The Anaconda is capable of inflicting massive amounts of damage, in fact being the only weapon that can take out the T-002 Tyrant's first form in a single shot, and it's limiter-removed variant in two. However, there are no extra .44 rounds available to the player, causing the Anaconda to become useless once all 6 bullets are fired.

This weapon also appears in Resident Evil: The Umbrella Chronicles as the Magnum Revolver. Like all of the weapons in REUC, it can be upgraded in various ways, including an upgrade which allows it to carry 12 rounds it can also pierce through multiple enemies. This gun can also be seen during the intro of the Resident Evil 0 scenario "Train Derailment", used by Billy. As is often the way with REUC, this is incorrect as the Silver Serpent is never obtained, or even seen, in Resident Evil 0.

Comparison to the Colt Python
The Anaconda is essentially a .44 Magnum version of the Python, and is more or less the same gun functionally speaking.

Interestingly enough, the Python externally is identical to the Silver Serpent, with the same recoil-absorbing barrel weight and custom grip. This makes little sense, as one is supposedly produced by Umbrella, and the other hand-built by Barry. It can be assumed this was done to cut down on the work load for two functionally similar weapons in-game.