Alexander Isaacs (clone)

Dr. Sam Isaacs Was an Umbrella Corporation scientist, in charge of the Nemesis Program. He is portrayed by Iain Glen. He greatly disliked his immediate superior, Major Timothy Cain, a feeling that Cain returned.

Immediately following the disaster in The Hive, it was Isaacs, who, at Cain's direction, experimented on Alice and Matt Addison. But disaster struck when Cain unwisely chose to re-open the Hive, despite the containment procedures. Zombies and Lickers escaped the facility, and the T-Virus overran Raccoon City, with Alice and Addison, now subjects in the Nemesis program, still inside.

Following the bombing of Raccoon City, Isaacs was dismayed to learn that both Alice and Addison were dead. But he was able to recover Alice's body from the wreckage of the helicopter she used to escape. After three weeks of experiments, Alice was revived with incredible new powers. Unfortunately, she retained her memories and escaped, being rescued by Jill Valentine, Carlos Oliveira, and Lloyd Jefferson Wayne. But Isaacs had one lastr trick up his sleeve, and as Alice makes her escape, he mentions that "Program: Alice" has been activated.