Annette Birkin

"William, I'm sorry. But I've got to put an end to G."

- Annette confronting her mutated husband. Annette_quote_-_Got_to_put_an_end_to_G.ogg

Dr. Annette Birkin was a virologist employed by Umbrella USA, and one of the administrators at their NEST facility beneath Raccoon City. She was the wife of fellow administrator Dr. William Birkin, and mother of Sherry Birkin.

Early life
Little is known of Annette's early life other than her training as a virologist which earned her a career at Umbrella USA's Arklay Laboratory, under the head of research, Dr. William Birkin. The two married in the mid-1980s and by 1986 Annette had given birth to their daughter, Sherry. In the early 1990s they began working as administrators at the newly-constructed NEST facility, where research into Golgotha was pioneered.

Raccoon City Destruction Incident
In the months after the viral outbreak in the Arklay Laboratory, the Birkins' relationship with Umbrella HQ deteriorated. After attempts to defund the project and remove them from the NEST, the facility began to operate independently. The two were able to strike a deal with the US military to surrender Golgotha to them for their own bioweapons project. Umbrella HQ's own spies within the military discovered this, and on the night of 22 September, the USS finally raided the lab and shot William. Annette arrived too late to stop him infecting himself with a Golgotha sample, and without DEVIL to stabilise his mutations he became a powerful creature simply dubbed as "G".

Over the course of the week, Annette left the NEST as its research subjects began escaping, and left to their sewer facility to analyse the buildup of "G" organisms that had made the underground their home. In the early hours of Wednesday 30 September she encountered a number of survivors entering the facility. Sherry herself and a survivor, Claire Redfield, entered the facility to escape the streets, but Annette's work made things difficult, and Sherry was eventually found by "G" and parasitised. Annette realised the real danger of this, that Sherry's mutation into a similar creature would be a threat to millions, and sent Sherry and Redfield out to the NEST to ready the DEVIL vaccine to stop her mutations. Annette remained in the facility, where she was then confronted by police officer Leon S. Kennedy and Ada Wong, who claimed to be an FBI agent investigating Annette. The two had entered the sewer facility to claim her Golgotha research, with Kennedy kept under the impression Annette was the cause of the t-Virus outbreak. After forcing Wong off a platform and injuring her, Annette left for NEST.

While at NEST, Annette encountered "G" and fired several rounds of an anti-B.O.W. weapon at him, but was thrown into a wall, fatally wounding her. In her short time back at the facility Sherry was successfully treated for the viral infection, but the facility began to self-destruct when Kennedy and Wong stole a Golgotha sample.

Further notes

 * Annette was fatally wounded by her mutated husband, William AKA "G", differently in three games that she appears in. In The Darkside Chronicles, she was fatally clawed by her husband in his 2nd mutated form before she shoots him, while in the original Resident Evil 2, she was fatally clawed by her husband in his 3rd mutated form after realizing he was alive. In Resident Evil 2 remake, she was grab and thrown into the steel wall by her husband in his 3rd mutated form after she shoots him, which he fatally injures her during the impact.
 * In the original game's Leon A, Claire B storyline, after suffering severe cranial damage from falling debris, Annette falls unconscious on the Main Shaft shortly after shooting Ada Wong. She, however, does not succumb to her injuries until after reuniting and apologizing to her daughter for neglecting her. This ending is used in the Resident Evil book, City of the Dead.
 * In The Darkside Chronicles, she dies the same way as she did in Resident Evil 2; however, this time she was trying to stop "G" only to be killed after she shot a bullet into him. She tells both Leon and Claire how to make the vaccine and dies.