2nd U.S.S.Squad was deployed into Raccoon City during the 1998 Raccoon City Destruction Incident. They were given orders to retrieve "Nyx"; an experimental bio-organic weapon, from the dockyards, and airlift it in a U.S.S. Chinook. The mission went wrong, either because of, or resulting in, its leader, Captain Rodriguez, disobeying orders in an act of betrayal to the company, which resulted in an immediate investigation of his friends and family. All other members of the 2nd U.S.S. were either killed, infected or missing-in-action. Whether or not they had also intended to defect remains unknown.