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In Resident Evil CODE:Veronica, it is possible to kill Nosferatu with a single shot to the heart with Alfred's sniper rifle, but it requires extreme accuracy. If the player hits it, a special animation will be shown of Claire saying "Gotcha!" while shooting him in the heart. Accomplishing this and completing the game will unlock a first-person viewpoint for the Battle Game mode.
In CODE: Veronica, there are two special cutscenes other than the one mentioned above. The first is if the player is unable to shoot out his heart with one shot. After multiple shots, Claire will exclaim "I got you now!" and shoot out the heart. The second triggers if the player uses the knife, with Claire saying the same thing in the killing scene, but stabbing his heart instead.
In Resident Evil: The Darkside Chronicles, both Claire and Steve fight Nosferatu in the compound below the helipad. He doesn't expel poisonous gas in this fight, but he does spit a bile like substance at the player if it takes too long to incapacitate him, as well as occasionally attack by using his tentacles to pull a chunk of ice out of the ground and throw it at the player's characters.
Alexander's normal human self only appears in The Darkside Chronicles, in which he had recorded a message to warn anybody who are listening that Code: Veronica is reaching critical stage, and that the Linear Launcher must be used to stop Alexia should she ever mutates out of control. This is also where Alexia directly, sarcastically, regarded him as "a miserable old man".