Alligator have been known to be infected with the t-Virus, and a number of individual cases exist.
A number of alligators were infected during the Raccoon City Destruction Incident. Most of these were infected attractions at the Raccoon Zoo, though another lived in the sewers. This much larger mutant grew from a baby which, like the urban legends, was flushed down the toilets, fulfilling the "sewer gator" myth.
This alligator became a threat to a band of survivors moving through the sewers in search of a way to the Raccoon City Underground Laboratory. It was killed when it bit into a fuel cannister, and a well-targetted shot caused it to explode inside its mouth.
Another alligator lived in the sewers of Sheena Island. Considering that the island was near Europe, this animal was probably transported as a pet like the one in Raccoon's sewers.
Resident Evil 2 The Alligator can be defeated in Scenario A by simply shooting it (though the monster is really tough), causing it to eventually smash a hole in the wall and escape. A small amount of ammo will appear a little later on. If the Alligator is defeated this way in Scenario A, it will come back again in Scenario B. In this Scenario, shooting the monster until it collapses will finally kill the creature for good.
The other more economical method involves releasing an emergency gas canister which the Alligator promptly picks up in its mouth. When the canister is shot, it explodes, taking much of the Alligator's head with it. Defeating it this way means it can be killed with only one hand gun round. Also if the monster is killed this way in Scenario A, it will no longer come back in Scenario B.
Resident Evil Outbreak File #2 In Outbreak File #2, the only strategy is to just swim over the area where it lives. If you really need to shoot it, stay on the dry land but close to the water. Alligator eventually will swim to the edge and try to attack you on land. When it trys, just shoot it. It will take quite a few shells from the shotgun to take it down, but using the Hunting Rifle will kill it in two shots.
- Like many other reptiles infected with the T-Virus (such as Yawn for example.) the increase in size has caused the skin to tear in places of the Alligator in the sewers.