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Annette's death in Resident Evil 2 (1998).
Annette's alternative death in Resident Evil 2 original.
Annette's death in The Darkside Chronicles.
Annette's death in Resident Evil 2 (2019).
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Annette was fatally wounded by her mutated husband, William AKA "G", differently in three games that she appears in:
In Resident Evil 2 original, she was fatally clawed by her husband in his 3rd mutated form after realizing he was alive.
In the original game's Leon A, Claire B storyline, after suffering severe cranial damage from falling debris, Annette falls unconscious on the Main Shaft shortly after shooting Ada Wong. She, however, does not succumb to her injuries until after reuniting and apologizing to her daughter for neglecting her. This ending is used in the Resident Evil book, City of the Dead.
In The Darkside Chronicles, she was fatally clawed by her husband in his 2nd mutated form before she shoots him. She dies the same way as she did in Resident Evil 2; however, this time she was trying to stop "G" only to be killed after she shot a bullet into him. She tells both Leon and Claire how to make the vaccine and dies.
In Resident Evil 2 remake, she was grabbed and thrown into the steel wall by her husband in his 3rd mutated form after she shoots him, which he fatally injures her during the impact. Annette survives long enough to personally administer the vaccine to Sherry, and dies in front of her daughter while begging for forgiveness.
Although Annette appears to genuinely care for William's well-being in the original game and The Darkside Chronicles, she appears more indifferent to his suffering and subsequent mutation in the remake. She flat out admits to Claire "we were more married to our work than each other." The Birkin family photo in the remake also shows William and Annette with flat, uncaring expressions, as opposed to the original photo that featured all three family members smiling.
