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In the Resident Evil 2 remake version, to unlock Annin Tofu in the The Tofu Survivor, the player must complete the minigame with either Konjac or Uiro-Mochi. Finishing the minigame with Annin Tofu grants the player the "Can't Get Enough" record which unlocks his model in the model viewer.
Annin Tofu's strategy revolves around cycling between his handguns for the right encounters. The Quickdraw Army is better used when burst damage needs to be done since it can fire shots very quickly, while the M19 is better suited for slow encounters when the player is not worried about other enemies in the vicinity. It is important to remember that the Quickdraw Army has a slow reload time and switching to the M19 after expending the Quickdraw Army's 6-round chamber might be more effective than attempting to reload it on the spot during an encounter.
Because Annin Tofu has a lot of Green Herbs and only one Red & Blue Herb, a good strategy is to create the Mixed Herb (R+B) in order to tank damage and not get poisoned, while the Green Herbs are used separately whenever the player is on caution.
Annin Tofu only has one Combat Knife, so it must be used strategically. The Quickdraw Army can shoot the bulbs of the Ivy Zombies to incapacitate them, so the knife can be saved for another encounter.
The ending area will likely be the hardest part. Since there is one G-Adult and a couple of Ivy Zombies, it'd be best to keep the Mixed Herb (R+B) until this area so Annin Tofu can tank the G-Adult's grab, then shoot the bulbs of Ivys to stun them to run past, and use the knife to counter an Ivy if the player is grabbed by one.
If you have enough ammo at this point, killing all enemies in this area with his handguns is a possible strategy, although you should make sure to not walk too far into the area where the G-Adult appears or else the Tyrant will be spawned from the Fire Escape area.