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Prime universe
(Capcom's primary storyline)

The Bio-Sphere was an underwater facility in the Atlantic Ocean. It was constructed directly underneath the Umbrella Waste Disposal Facility, and was abandoned sometime before 2002. The facility was later used by a group of bioterrorists led by Morpheus D. Duvall, who sought to hold the United States and China hostage with the t-Virus in exchange for a large sum of money. A missile silo was constructed adjacent to the Bio-Sphere for this purpose. At some point, the facility experienced a biohazard and its personnel were transformed into zombies. The facility was destroyed when the t-Virus missiles detonated within the Bio-Sphere's missile silo.

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