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Bitores Méndez will be formally fought at the Slaughterhouse in Chapter 2-3 of the main game. As the player approaches the barn a cutscene will play where Leon enters it himself and the chief ambushes him. The player must dodge his attack via a quick time event or they will get a game over scene. Being successful initiates the fight after the scene. Ashley will not be present during the fight, as she was left outside.
Various ammo is littered throughout the slaughterhouse during the fight as well as a full set of herbs. Leon can climb up the ladder to collect it, but Bitores Méndez will attack the player by stretching himself instead of climbing up the ladder also.
After Méndez sustains enough damage, a cutscene will play where the top half of his body leaves his lower half and then the fight resumes. He will now move around by wrapping his appendages around the horizontal beams and jumping from one to another and will now use a different set of attacks.
Upon defeat, Méndez will drop 30,000₧ and his False Eye. When the player picks up the False Eye, a short cutscene plays where Leon does so and then notices that part of the wall burns down. When gameplay resumes, there is now an exit and the player can use the "JUMP OUT" prompt to leave.
Shortly after fighting the chainsaw sisters in Chapter 6, Leon and Ashley are confronted by Bitores Méndez, and are forced to flee. During this sequence Ganados(their health is lower during this sequence) will aid Méndez in his pursuit of Leon and Ashley. The player will get a game over should Méndez grab ahold of Ashley. The sequence ends after the player reaches the bridge and a cutscene starts in which the bridge collapses.
Like in the original, Méndez is fought in the slaughterhouse. His boss fight is similar to the original, but the cutscene before the fight lacks quick time events. His moveset is similar and his attacks can be parried or evaded when prompted. When Méndez is damaged enough, he will leave behind his lower body and use the ceiling to move around. He will occasionally throw burning planks of wood at the player which can be dodged by crouching, and should he grab ahold of gas barrels, the player should shoot them to avoid damage and damage Méndez.
Upon defeat, Méndez will drop his false eye, which is no longer a key item but a collectible. The player can then exit the slaughterhouse through a window Ashley broke.
