Slam - The Blob slammed it's anchor in a downward motion, sending the player into the dying status.
Swing - The Blob swung it's anchor toward the player. If hit, the player instantly went into the dying status.
Acid Blood - When the massive growth on it's back was shot, it would release a stream of acid, stunning the players who are near and doing minor to high damage (Depending on the difficulty mode).
Grab - The Blob would grab the player off the ground. There was no dodging prompt for this attack. If grabbed, the player had a small time frame of rescue. If not reached, the Guardian would thrust it's anchor in an upward motion, impaling the player and resulting in an instant death. The grab animation was slightly faster than the Executioner's.
The Blob was unable to run, making them quite easy to escape from. The small eye located on the back of the large tumor was the best weak point. When shot or stabbed, the eye would bleed violently and 'spin'. If you keep shooting the eye, the Blob would easily die (On easier modes, one shot from a Magnum would kill the Blob if shot in the eye).
The large tumor growth on it's shoulder was another weak point where several hits from a shotgun would kill or severely injure the Blob. Melee weapons such as the Combat Knife are ineffective as the Blob would spray acidic blood when injured. However, it was possible to "knife" the Blob.
Continuous damage to the head or the tumor on the shoulder could take the Blob down to it's knees, leaving it vulnerable to the following melee attacks; Jill: Sweep Kick / High Kick - Chris: Uppercut / Straight. A single shot in the eye on it's tumor would always stun the Blob.
During their search of the estate for Oswell E. Spencer, Chris and Jill who lost their weapons resorted to using booby traps against the Blobs. These spiked platforms would drop from above like a moving ceiling, crushing and impaling anything caught beneath them. Though the Blob may be able to stop the platform from crushing them sometimes by using their anchor at that time, the player could either melee them; Jill: Flip Kick - Chris: Haymaker or throw a Flash Grenade to stop and kill them.