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A maximum of 13 Blobs could appear on Veteran mode:
On easier difficulties, the number of Blobs dropped down significantly to as low as 5.
In the prison block, a Blob passed Chris and Jill from a platform above. If you could stun it at this time with Incendiary Grenades, you could reach the top floor before it escaped and defeat it. It counted as a secret Blob.
The higher that the difficulty that you played on, the faster that the Blob's attacks would be. The "slam" attack would be insanely fast while the "swing" attack could move so quickly. It was almost impossible to dodge. It was recommended that one should run past the Blob after landing a second melee attack as trying to turn around and run would almost always result in getting mauled. The grab motion would also increase in speed to where it was impossible to dodge if the animation started up. The Blob's attacks moved at their quickest on "Professional" mode.
This creature was sometimes referred to as "Guardian of Insanity" (Or "Keepers of Madness" or any variation), although this was a descriptive term and not a name, referring to the fact that they served as "guards" around the Spencer Estate which was a site of insanity.