The Bloodshot (ブラッドショット,Buraddoshotto?) is the result of a C-Virus Zombie mutating in response to excessive damage, similar to the V-ACT process. They were encountered by Leon, Helena, and Ada during the Tall Oaks incident. They were first encountered at the Tall Oaks gun store.
Following their use as B.O.W.s by Neo-Umbrella, the black market trade organization known as Umbrella Co. had acquired C-Virus bio-weapons through unknown circumstances. They were likely sold on the black market from this point onward. They would also be deployed to the Antarctic Base for Umbrella Co. mercenary training and anti-B.O.W. weapons testing.
In one specific situation, however, C-Virus B.O.W.s were used at the Antarctic Base in an attempt to dispose of unwanted liabilities.