"Chapter 2-1" could mean the following:
- Chapter 2-1 of the Resident Evil 4 storyline.
- Chapter 2-1 of the Resident Evil 5 storyline.
- Chapter 2-1 of Resident Evil 6's "Leon Story".
- Chapter 2-1 of Resident Evil 6's "Chris Story".
- Chapter 2-1 of Resident Evil 6's "Jake Story".
- Chapter 2-1 of Resident Evil 6's "Ada Story".