"Chapter 2-1" could mean the following:
- "Chapter 2-1" of the Resident Evil 4 storyline.
- "Chapter 2-1" of the Resident Evil 5 storyline.
- "Chapter 2-1" of Resident Evil 6's "Leon Story".
- "Chapter 2-1" of Resident Evil 6's "Chris Story".
- "Chapter 2-1" of Resident Evil 6's "Jake Story".
- "Chapter 2-1" of Resident Evil 6's "Ada Story".