(Capcom's primary storyline)
Chicago is a major city in the United States located in the State of Illinois against Lake Michigan.
History with Umbrella
Umbrella U.S.A. operated a major branch in the city, and it was through here that other facilities in the US, such as those in nearby Raccoon City, were directed. John Clemens was transferred to the Arklay Laboratory from Chicago to assist in the t-Virus Plan.[excerpt 1]
Chicago was the site of the Alexander Institute of Biotechnology, a biomedical research facility involved in the A-Virus incidents of 2014. Professor Rebecca Chambers was employed there and used the institute's resources to develop a partial vaccine against the virus. The institute was attacked by Maria Gomez on the orders of Glenn Arias to retrieve Dr. Chambers' research and to prevent her from continuing her work.
- Excerpt from Resident Evil 2:
"Ada Wong? I've heard that name before. Now I remember. One of the men from Chicago who came to assist the t-Virus research used his girlfriend's name as his password. 'Ada' and 'John', I believe." - Annette to Ada Wong.