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"CLAIRE IS A LIGHT-HEARTED, ARTICULATE, MORDERN WOMAN. WHILE SHE CAN BE A BIT OF A TOMBOY AT TIMES, SHE IS SOMEWHAT WILD. SELF-CONFIDENT AND EXTROVERTED, CLAIRE IS TYPICALLY THE FIRST PERSON TO TRY SOMETHING OTHERS WOULD NOT."
— Resident Evil 2 Nintendo 64 Manual, p.3
According to Alyson Court, Claire's likeness was based on Neve Campbell in Resident Evil 2 and Liv Tyler in Code: Veronica.
The designs on the jackets of both of Claire's primary outfits in Resident Evil 2 and Resident Evil Code: Veronica contain references to the band Queen. "Made in Heaven" (from RE2) and "Let Me Live" (from CV) are both names of Queen songs. She shares this trait with Billy Coen (whose tattoo, "Mother Love", is also the name of a Queen song).
Claire's Resident Evil 2 original outfit has a "Made in Heaven" design on the back. The same logo has her brother, Chris, on the jacket of his alternate outfit, in Resident Evil.
During her story in Resident Evil: Revelations 2, Claire quoted to Moira about herself almost being a Claire sandwich after nearly squished from a booby trap is a reference to Barry's famous joke about the "Jill sandwich".