The Python found in the remake is known as Magnum Revolver (or Silver Serpent). To acquire it, the player must utilize the same four crests in the same fashion as the original, except the puzzle is done in the mansion's courtyard on two graves that are right next to each other. By inserting the Wind Crest into the right grave, three others will appear. After inserting them into their respective places in the left grave after pushing the switch on their backs, the grave will rotate, revealing the Python.
For Deadly Silence, the magnum's model was changed to make it look like the Silver Serpent.
The Python is very powerful and will normally decapitate a zombie with one shot and deal massive damage to bosses, and thus, ammunition is made scarce to balance gameplay. In the remake, a maximum amount of 24 (12 on Hard) rounds can be found, with six already in the gun.
- Colt Python (Original/Director's Cut)
"Colt Python. Powerful gun that can be loaded with .357 magnum rounds. MAGNUM ROUNDS loaded."
- Magnum Revolver (when loaded) (Resident Evil Remake)
"It's loaded with magnum rounds."
- Magnum Revolver (when empty) (Resident Evil Remake)
"The gun fires .357 Magnum rounds. A powerful firearm, but it takes skill to handle it."