Ethan Winters

===Creating a serum===
{{Quote|My family and I...our bodies are contaminated. I can't leave the property unless I get it out. Same goes for Mia. We need the serum. It should clear whatever this stuff is out of the body. As long as you're not too far gone.|Zoe explains to Ethan that nobody can leave until a serum is created.}}
After acquiring all the dog heads and escaping the main house, Ethan made it to Zoe's trailer, once again being phoned by her. Impressed with his progress so far, Zoe explained her dire situation to him - her entire family, including herself and Mia, were 'contaminated' and needed some sort of serum to cure themselves. Believing that her mother Margeurite may have hidden some in the [[Old House]], Zoe instructed Ethan to start the search there. While investigating the area, Ethan briefly reunited with Mia on the other side of a chainlink fence and started to question her about what she knew despite her amnesia, but Lucas appeared from behind Mia and kidnapped her. Once Ethan got the Crow Key and headed towards the second floor, Marguerite ambushed him and threw him down a flight of stairs. The impact of his fall caused the wooden floor beneath Ethan to break and send him plummeting down a hole in the ground, leaving him at the mercy of Marguerite and her mutant bugs. Ethan retaliated by shooting at Marguerite from the hole, eventually weakening her to the point where she stumbled and fell into the pit, allowing Ethan to climb back up from the hole.

On the second floor, Ethan discovered the mummified corpse of a "[[D-Series]]" child, the basis of the serum. However, he was unable to enter the area where the D-Series arm was stored, as it could only be accessed with Marguerite's lantern. Ethan returned to the pit where he fought Marguerite, only to find that she had escaped with the lantern through a hidden tunnel. Ethan followed the tunnel and arrived at an old greenhouse, where he was confronted by a grotesque, mutated Marguerite, but he defeated her causing her to calcify and crumble to pieces, revealing the lantern inside of her. Ethan picked up her lantern and used it to access and grab the D-Series arm from the old house.

After agreeing to meet Zoe back at her trailer, Ethan was instead contacted by Lucas, who had managed to capture her. He told Ethan that the D-Series head could be earned back if he agreed to participate in an "activity" he put together, and before hanging up, Lucas urged Ethan to look in the fridge which contained Anderson's now decapitated and partiallly mutated head along with a note saying, "The pig is waiting for you in the dissection room, bitch". Ethan backtracked to the dissection room in the basement of the Main House, and found the body of the beheaded Anderson with a sign saying "Prove you're a real man and stick your hand down this pig's throat!". He reluctantly did so, feeling sorry for the deputy, and pulled out the [[Snake Key]] which Lucas explained would help him find the two key cards he needed to join the "party" in the barn. After managing to get his hands on both keycards, Ethan was finally able to enter the barn.

Once inside, Ethan sat down in front of a TV and was greeted by Lucas who proved that he had the D-Series head and refused to give it up. As Ethan progressed further into the barn, he realised that it had been rigged full of traps by Lucas, who gloated over various speakers throughout the complex. After successfully evading several Molded assaults, Ethan made his way into a puzzle room which Lucas intended to be impossible to solve - however, he outsmarted Lucas and made him retreat, leaving behind the D-Series head but not before issuing one final threat to Ethan through the monitor system.

Once arriving at the Boathouse and finding Mia and Zoe, Ethan freed the two women and gave the serum ingredients to Zoe to make the final product, intending to use a docked boat as an escape. However, as Ethan grabbed the two serum samples Zoe had created, a heavily mutated Jack burst through the building and grabbed him, forcing a final showdown between the two. Ethan managed to take out the many eyes covering Jack's body, and even though this alone was not enough to keep him down, a quick suggestion from Zoe led Ethan to inject Jack with one of the serums in desperation, causing him to rapidly calcify. With one remaining serum left, Ethan made the difficult choice of curing his own wife Mia over Zoe.