Simmons listens to Carla Radames taunt him over the phone about how she is just turning him into the monster he always was. Angered, he crushes his phone before he can hear the rest of Declaration of Victory. He turns to see Leon and Helena, telling them his actions were justified to maintain the global political order. Seething with anger at Carla's betrayl, Simmons gives in the to the infection, turning into a freakish satyr and then a monstrous k9.
Carla (on radio): "I'm just giving you exactly what you gave me, Simmons."
"At first you'll be afraid, but don't worry."
"You're just becoming the monster you always were."
"You and everyone else on the planet."
Leon: "Give it up, Simmons. We've got you."
Derek C. Simmons: "You still chase me while that woman is on the loose?"
Leon: "What woman?"
Derek C. Simmons: "That traitor, Ada Wong. Who knows what she's got in store."
Leon: Another team was sent after her, but you, Simmons, you're all ours."
Derek C. Simmons: "Are you here to avenge the president? Is that it? You fool. Had he disclosed the truth behind Raccoon City, the U.S. would have lost all its authority, and the global political order would have collapsed!"
Helena: "So to avoid one possible disaster you create another? No matter how many people die!"
Derek C. Simmons: "He had to be stopped! He was leading my country, this world, into complete chaos! That woman... How dare she do this to me!"
Carla Radames (on radio): 「あなたが私にくれたものそっくりお返しするわ…シモンズ」
Leon S. Kennedy: 「諦めろ もうおまえに逃げ場はない」
Derek C. Simmons: 「私を追ってどうする？ あの女を追え」
Derek C. Simmons: 「エイダ・ウォンだ」
Leon: 「あいにくと そっちは仲間が追ってる」
Derek C. Simmons: 「大統の仇か？バカめ」
Helena: 「違うわ！ 世界を破滅させているのはあなたよ！」」
Derek C. Simmons: 「まだ分からんか！」
- Hideki Osada, ed (2012). BIOHAZARD 6 Official Complete Guide. Famitsu. ISBN 978-4-04-728612-2.
- Resident Evil 6 Signature Series Guide. BradyGames. 2012. ISBN 978-0-7440-1422-8.
- BIOHAZARD 6 STORY GUIDE. Capcom. 2013. ISBN 978-4-86233-392-6.