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The Flash Grenade in Resident Evil 6 bears the same design as Resident Evil 5 only lacking somewhat in its usefulness since there are no Plaga-infected enemies. It can still be useful for making a getaway or avoiding enemies. This grenade can still stack up to five grenades per item slot.
This type of grenade appears only in Chris' and Jake's campaigns and is common in availability, often finding them randomly in boxes. The Flash Grenade is the only grenade that Jake can acquire in his campaign. It can be effective against some enemies that hatch from Chrysalids; a Flash Grenade will instantly kill a Mesec and will stun a Strelac, allowing the player to follow-up with series of kicks.