(Capcom's primary storyline)
"Really, I simply don't understand American humor."
He was in Raccoon City when the outbreak occurred. Shortly before Raccoon City's destruction, Frederick stole t-Virus and G-Virus samples from the branch and fled. He can be considered the main antagonist of Resident Evil: Degeneration due to his behind the scenes involvement in the events of the movie.
He had released the t-Virus at one of the planes heading for Harvardville Airport and blew up the trucks full of vaccine supplying the survivors and U.S. Marine Corps in order to disguise the incident as a terrorist act while blaming Senator Ron Davis for involvement.
He is also responsible for setting the time bomb that destroyed a WilPharma building, and trying to smuggle G-Virus data from the security cameras catching Curtis Miller, the t-Virus, its vaccine, and the G-Virus to profit from General Miguel Grandé.
- Biohazard Archives II - page 220