He was killed by a co-worker Monica, who saw him as being in the way between her and Dr. William Birkin's research, which she stole after shooting Frost at point-blank range. 
Frost's name might be a pun to the scenario's theme due to it involving some rooms being frozen.
Frost has two unlockable versions. One starts with a [[Recovery Pill], while the other is shown to have an injured hand and starts with a mixture of a Red and Green herb. Both are George-type characters.
Interestingly, the injured version does not start in danger status like most characters with injuries on their bodies do (E.G. Andy for instance).