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Within their initial concept art and their full depiction in the 2019Resident Evil 2 remake, their origins as the result of human industry radically and negatively impacting natural ecology and dwelling in the sewers of Raccoon City hearken to the ideas of undesired life born from volatile mutagenic waste byproducts of excessive human consumption, and being actively harmful entities that dwell underground in Raccoon City's waste system bears resemblance to the titular C.H.U.D.s (Cannibalistic Humanoid Underground Dwellers) of the 1984 sci fi horror film of the same name.
The design of the G infants in Outbreak is radically different to that of both Resident Evil 2 and Darkside Chronicle. In that game, G infants have slightly serpentine bodies with eyeless domed heads and a pair of arms, giving them an eerie resemblance to Xenomorphs's chestburster stage from the Alien franchise.
G infants (G幼体,G yōtai?) are referred to as "G-Imago" in the English version of Resident Evil Outbreak. An "Imago" is an insect that has almost completed its metamorphosis and visibly and biologically resembles the adult but without wings.