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Hand grenades return in Resident Evil: Operation Raccoon City, where they are used by both the Umbrella Security Service and the Government SpecOps. Players can carry up to three at a time. Grenades are found scattered throughout various segments of the map. Stun and Incindiary grenades also appear in the game.
Beltway and Chris Redfield can put grenades into zombies' mouth making their head to explode and damaging nearby enemies as well.