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"A powerful hand-thrown explosive device. Effective against groups of enemies."

Hand Grenade is an item in Resident Evil 5 sporting a design similar to a high explosive grenade or a smoke canister. Resident Evil 5's inventory system allows the players to carry five grenades per item slot. Hand Grenades sell for ₦250.

While fighting the U-8 on the elevator, once it is stunned, if a player has one or more Hand Grenades in their inventory, they can run up to its open mouth, and perform a special action command where the player tosses a grenade into its open mouth, damaging the creature, and exposing its brain.

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