"Mark's favorite handgun. It uses 9mm parabellum rounds."
— Item description
(Like other Personal Items, Mark's Handgun cannot be discarded or transferred to other characters)
Externally, Mark's Handgun is the same as the standard R.P.D. Handgun. It uses the same ammunition and has an identical ammo capacity. The damage it causes is lower (130 hp) but it will inflict 90% of the firepower at mid and long distance shots, unlike the common handgun found in-game. The weapon also uses the same Magazine of the standard Handgun.
- Mark and his character types will auto equip this handgun. However, he prefers to load it and use another powerful weapon if he has it, leaving it as a backup weapon.
- In Resident Evil Outbreak File #2, Mark starts off with a loaded Handgun Magazine as his Extra Item.