"While avoiding blasts of flame, we proceeded through the smoke-encased hotel. We now knew the true meaning of "hell.""
— Scenario menu
Hellfire takes place throughout the rooms of the burning hotel, the Apple Inn. It is infested with lickers. This scenario includes the only appearance of a Suspended, which acts as the scenario boss.
Four survivors found themselves surrounded by a horde of zombies, as they run into an alleyway, they become trapped when they find zombies at either end. With nowhere else to go, they choose a third way - a door leading away.
Meanwhile, two firefighters - Len and Charlie - inspect the boiler room of the Apple Inn. After the boiler shows signs of a malfunction, the two retreat, but are too late to avoid an explosion caused by the boiler. The ensuing damage to the building forces the structure to lean over the door, blocking the three survivors within the Inn's courtyard. As the survivors travel around the burning hotel, they run into various zombies, lickers, and dying or already dead hotel visitors. When the group reach the Apple Inn's front lobby, they fight a half-transformed Licker known as "Suspended" which appears to be a zombie-licker hybrid. Soon after the Suspended's death, a firefighter breaks open the door and helps all of the remaining survivors out of the Apple Inn. The firefighter will have a talk giving hope to the survivor and after that, will remember his fallen comrades.
In Hard and Very Hard modes, the players would have to notice if there is smoking coming down some doors; if those doors are open the character would suffer a hit from the "backdraft" which would deal a lot of damage.
The Suspended boss fight will have two re-spawning lickers which would protect her from the survivor's attacks. Both of them can be incapacitated if the player rings the fire alarm in the reception; if this is done in Very Hard mode, the lickers would gather in-front of the Suspended as if they want to protect her.
An Unknown survivor would be found resting in one of the bathrooms. If a player goes to talk to him it would warn about the "creatures with the spear-like tongue " that pierced his torso. No matter what, this survivor will die.
Selecting Cindy as character will make it the only time that Cindy meets Alyssa and Yoko as AI partners, as well as making the only time where the three females reunite.