(Capcom's primary storyline)
In 1967, the Spencer Mansion's construction was completed. In honor of the occasion, George; Jessica and Lisa were personally invited by Oswell E. Spencer - future co-founder of the Umbrella Corporation - to his estate to celebrate. George was unable to come due to a conflicting schedule, so Jessica and Lisa went on their own. Arriving at the estate, they were immediately taken away by Spencer's employees and hidden in an underground section of the courtyard. To keep George out of the know while awaiting his arrival, it was concocted that the two had left quickly to see a hospitalized aunt.
The two women were used as test subjects for the recently discovered Progenitor Virus, with Jessica being used for "Type-A" testing. Fearing the worst was yet to come, Jessica wrote up an escape plan to her daughter in the hopes they'd escape before it was too late. Unfortunately, before the note could get to Lisa, Jessica was killed by Umbrella and disposed of. In her place assumed an impostor to keep Lisa satisfied, however, she was not able to deceive the girl for a long time.
- Jessica's first appearance in the franchise was in the non-canon work Resident Evil: The Book (BIOHAZARD THE BEGINNING in Japan), based on files removed from the 1996 game before release.
- The 2002 Resident Evil remake includes a lighter with Jessica's name engraved on, a present for George.