During the T-Virus epidemic that hit the city, placing more value on his own life than his daughter, the mayor fled Raccoon City once the outbreak became evident. Katherine ended up in the protective custody of Brian Irons, chief of police at the Raccoon Police Department. Increasingly deranged, he planned to kill her and turn her into a taxidermy trophy. At some point, she became aware of the police chief's intentions and ran away from him, something he deliberately allowed in order to hunt her down later. On September 29, Irons finally killed her, though accounts differ as to if she was killed in the Raccoon Police Station or the Orphanage. Likewise, the sources differ about where Irons took Katherine's body, with an account stating that he took her to his secret Taxidermy preparation room under the Police Station while on another account, he left her at the Orphanage.
In the non-canon scenario, "The Ghost Survivors", Katherine managed to kill Chief Irons in self-defense, taking the keys to the prison cells shortly afterward. She fights for survival across the city to the precinct, where she finds Ben Bertolucci in the jail cell. She frees him and the two flee the city together.