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Prime universe
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Katherine Warren did not appear in Hideki Kamiya's script for Resident Evil 2, a stage in game development also referred to as "BIOHAZARD 1.5". She was created during the writing process for Noboru Sugimura's mid-1997 script. After coming up with the idea of Umbrella bribing city officials, including Brian Irons, his psychopathic nature was slowly developed, with the minor role of Warren being one of the eventual outcomes. She would not receive a name until the 2019 remake, before which she was simply known as the "Mayor's daughter".

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