Placing more value on his own life than his daughter, the mayor fled Raccoon City once the viral outbreak became evident. Katherine ended up in the protective custody of Brian Irons, chief of police at the Raccoon Police Department. Increasingly deranged, he planned to kill her and turn her into a taxidermy trophy. On September 29, he finally killed her, and stored her body in the nearby Orphanage to prepare for her dissection and embalming.
In the non-canon scenario, "The Ghost Survivors", Katherine finds out about Chief Irons' plans and promptly kills him in self-defense, taking the keys to the prison cells shortly afterward. She fights for survival across the city to the precinct, where she finds Ben Bertolucci in the jail cell. She frees him and the two flee the city together.