The G-Virus Seizure Operation was the mission undertaken by U.S.S. Alpha Team to retrieve all samples of the G-Virus from William Birkin's laboratory. Initially when the team had arrived, Birkin refused to hand over the samples, but knocking over an item made a sound similar to a gunshot, which caused one of the U.S.S. members to shoot and mortally wound him. Alpha team made off with most of the samples, but Birkin still had one left in his hand and injected himself with it. The now mutated Birkin hunted down and killed almost all of the members, except for the team's leader, HUNK. Due to HUNK having one of the samples before being attacked, he escaped through the sewers and to the police station. There, he was rescued via helicopter from the rooftop, making the operation a success.
The mission is referred to in the BIOHAZARD 2 Official Guide Book as dakkai keikaku (奪回計画)