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Spencer makes a cameo in Ultimate Marvel vs. Capcom 3. In the Nemesis ending, he is shown speaking with Director Colcord, about an "improvement" made to Nemesis.
Although his birth year was given as 1931 in the BIOHAZARD 5 kaitaishinsho guide, this conflicts with some reports in the game itself as well as prior elements in the franchise, namely his friendship with James Marcus since their college years, as Resident Evil 0 implied the latter was born in 1918. The RE.Net Recollections timeline changed this to being 1923.