The Prelude is the opening scenario to Resident Evil 6, serving as a tutorial stage.
Before life and death in Lanshiang, China, Leon and his new partner, Helena fall into the car. Helena was unconscious and Leon was managed to get her out there.
Waking up outside supposidly under attack from a helicopter, Leon wakes up and drags Helena into a nearby building where he continues to support her until he is able to find a herb and combine it to make Health Tablets for her. Upon doing this, he gets ambushed by a BSAA zombie, dispatching it quickly with its knife. Now able to walk, the two make their way outside after Ingrid Hannigan suggests a route for them, only to narrowly escape an explosion by jumping into a nearby helicopter.
Leon takes over control of the vehicle as the pilot dies, however he turns into a zombie and attacks Helena, prompting Leon to finish him off, before the helicopter crashes into a building, despite his best efforts. Surviving the crash, they make their way into a large chamber where something large appears in front of them. Leon remarks "Back for more?" and then the prelude ends.
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There are a couple differences in Chapter 5:
- Helena wasn't too weak to walk on her own
- The helicopter is actually piloted by Ada Wong and doesn't attack them
- Leon doesn't speak about the dead BSAA agent
- Helena doesn't need medical attention
- Derek C. Simmons is in his human form when the two arrive in the chamber