(Capcom's primary storyline)
RED QUEEN was a highly advanced and self-aware Umbrella computer. Its primary objective is oversight and protection of Umbrella assets. Its secondary objective is the protection of Umbrella officer lives. Its third objective is unknown because Albert Wesker destroyed the computer screen before it was revealed.
It was originally integrated into the Arklay Laboratory but was moved away by Sergei Vladimir during the t-Virus outbreak in 1998. Albert Wesker first met RED QUEEN in that same year. While trying to retrieve Umbrella's information through a computer, RED QUEEN cut off his access and introduced itself. This caused Wesker to destroy the computer's monitor in a moment of anger and to vow take revenge on RED QUEEN.
It was relocated to a facility in Russia, and by the time of 2003, it gave a report on a biohazardous outbreak to its leader, Sergei, caused by Wesker. It was last seen by Wesker in the Russian Facility, where he managed to save the entire Umbrella history into a single RED QUEEN-integrated disk. He then erased the computer's memory, finally claiming his revenge on it, the process of which also causing a huge black-out throughout the facility. It was also responsible for controlling the Tyrant-Armored Lethal Organic System, a variant of the Tyrant Bio Organic Weapon.
- The name "Red Queen" is taken from the first Resident Evil film in which a computer system is in charge of the facility beneath the Looking Glass House, responsible for the deaths of the researchers, and later the Umbrella soldiers that come to investigate.
- The memory erase code for RED QUEEN is "ELC34791203409K0I02390".
- "Red Queen" may also be a reference to the evolutionary hypothesis of the same name.
- A variation of the RED QUEEN A.I., named Red Queen Alpha appears in Resident Evil: Revelations 2's Raid Mode, where it runs the battle simulations that the Overseer places the player through.