"A deadly virus has been unleashed on the population of Raccoon City. "Resident Evil: Apocalypse" is a terrifying adventure in survival horror. Milla Jovovich returns as Alice, one of only two survivors of the contained biochemical disaster in the first "Resident Evil," the $100 million hit that serves as a prologue to the all-out action and horror of "Resident Evil: Apocalypse".
The film begins where the first film left off, with Alice in the heart of the ravaged and deadly Raccoon City. She has been subjected to biogenetic experimentation by the vast Umbrella Corporation and become genetically altered, with super-human strengths, senses and dexterity. These skills, and more, will be needed if anyone is to remain alive. Alice is joined by Jill Valentine (Guillory), a recently demoted member of Umbrella Corp’s elite Special Tactics and Rescue Services (S.T.A.R.S.), Terri Morales (Holt), Carlos Oliviera (Fehr), L.J. (Epps), and Nicholai (Ward) who must survive and escape what is quickly becoming a City of the Dead. To reach their goal, they will need to battle their way through the relentless onslaught of the ravenous undead, as well as Umbrella forces and terrifying bioengineered weapons, the most deadly of which is the colossal, heavily armed assassin, Nemesis."
— Official synopsis