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When Claire goes to look for survivors in the airport she was given an umbrella that had exactly the same colour pattern as Umbrella corporations logo to use as a weapon. Claire herself notes the irony.
Soundtrack clips from Resident Evil 2 game are used in the theatrical trailer.
When Frederic Downing shuts his office door, the sound of it closing is the same sound of players closing doors in the early Resident Evil games.
Hollywood's only contributions were the voice actors and live motion capture actors.
In the Raccoon City flashback, while Leon talks with Claire, it shows Leon wielding his VP70 pistol and Claire wielding a M1100 Shotgun, which is odd, since Claire can't acquire a Shotgun in her storyline of Resident Evil 2.
The Army Rangers appear in this film in several scenes, but are referred to in the English localization as Marines. This caused some confusion among viewers due to them wearing Army Combat Uniforms and not the MARPAT uniforms typical of Marines at the time.