It is 2006. The White House has been subjected to a massive security breach in which computer files privy only to President Graham have been stolen. During the investigation, power is cut and the fortress is attacked by Zombies, adding more questions. The following day, TerraSave activist Claire Redfield visits to petition the construction for refugee centres for those affected by bioterrorism. In a chance meeting with US Army special operations soldier Leon S. Kennedy, the two are able to link the incident at the White House with a child's drawing of another bioterror incident on the other side of the world.
Production of the series is being handled by TMS Entertainment and Quebico, the latter providing the 3D animation. As is typical with Capcom's licensing since Resident Evil 4, producer Hiroyuki Kobayashi has creative oversight of the project to maintain Capcom's vision and the flow of canon with the games. What is known so far is that Quebico and TMS chose to focus on ultra-realism with the animations, from character expressions to environmental effects like dust. Toshiyuki Morikawa stated during the AnimeJapan 2021 that he had not started recording the voice lines for Leon yet by that time (March 27).