The film's style, a departure from the previous twofilms, was intended to welcome in more fans of anime such as PSYCHO-PASS and live-action horror films rather than cater entirely to established fans of the games. Vendetta was the first and only film in the CG franchise to recieve a limited theatrical run in the United States and Canada, which was hosted through Fathom Events.
A Mexican Army team supervised by BSAA Captain Chris Redfield investigates a mansion linked to a B.O.W. smuggling operation, which is infested with zombies infected with a new viral strain. There he finds Glenn Arias, a black market dealer wanted by Interpol, but Arias gets away when the mansion explodes. He is soon joined by one of the BSAA's advisors, Dr. Rebecca Chambers, who begins developing drugs to combat the virus encountered in the mansion. The laboratory is attacked by one of Arias' accomplices at the end of her research, and Chris saves her from infection. Following the attack, they get the attention of DSO agent Leon S. Kennedy. Concluding Arias is involved in an upcoming terrorist attack they head out to New York to find him before it can take place.
The film was announced on October 15, 2015 in a mission statement on Marza Animation Planet's official website. It was referred to as a "reboot", though in regards to the staff being different from the first two, and not in terms of plot. The official title was announced on March 25, 2016, being formerly called "BIOHAZARD CG3".