The "George A. Romero script" was a series of drafts for a proposed Resident Evil film in plans since October 7, 1998.
Romero was hired on as writer-director in 1998 following the dismissal of Alan B. McElroy, who had written an earlier version of the film. His script was well liked by producer Robert Kulzer, but executive interference by Constantin's Executive Producer Bernd Eichinger halted production owing to concerns the level of gore wanted for the film was excessive for German cinema. With Germany's film industry being regulated for content, it would have had a poor domestic showing, being restricted to certain theatres and video stores and not be allowed on TV. In the words of Romero, he felt Eichinger "wanted something prestigious" instead of a video game adaptation.
The story begins at a top-secret laboratory in Pennsylvania's Arkley Forest. Chief researcher Dr. John Marcus alerts his superiors to a biohazard and pleas with them not to send rescue as he is torn apart by his colleagues, driven mad by the infection. Meanwhile, Mohawk ranch owner Chris Redfield is out feeding the eagles when he is disturbed by an unusual creature in the distance. He returns back to his girlfriend Jill's apartment and they have sex; meanwhile, Chris' ranch is attacked by a pack of hyperaggressive dogs which terrify the horses before mauling a ranch worker, Rake.
Later in the morning, news filters over to the Army about the outbreak, and Col. Albert Wesker, CO of their S.T.A.R.S. special operations team, begins preparations for a rescue operation. As S.T.A.R.S. is based 500 miles away from the lab, the four soldiers of Bravo Team have been under-cover in Raccoon City for the past six months as a first response team. Among these are DiSimone, Russo, Williams and Jill Valentine herself as team leader. Jill puts on her uniform and rushes out to meet with the team, deciding not to warn Chris of the situation. Bravo Team drives out into Arkley Forest and reaches the Arkley Mansion, the surface façade of the laboratory. Before they can get inside, however they are attacked by the guard dogs and all but Jill are killed. With one of the dogs swallowing a tracking beacon, Wesker orders the entire city be evacuated while his own Alpha Team takes on Jill's responsibilities.
Chris leaves Jill's apartment to see the evacuation operation taking place. The Pennsylvania Army National Guard is unable to reveal the true nature of the emergency, and when the cover-up that a military transport plane crashed is debunked by the local Sheriff the evacuation turns violent. During the struggle Chris commandeers a jeep and drives out to the ranch, where he finds it destroyed. A mortally wounded Rake warns him of monsters before dying, pointing out their direction as the Arkley Mansion. Chris puts down his racehorse, Lucky, before heading out to investigate.
Chris arrives at the mansion just as Alpha Team arrives, watching through the bushes as they recover Jill's bloody dog-tags. The dogs return to attack Alpha Team, with them losing Joseph Frost and almost Wesker himself. Chris himself is almost exposed, but takes the opportunity to sneak in through a tunnel to spy on them. Alpha Team enters the mansion, where Wesker explains their mission: they are entering an underground laboratory complex rescue Marcus and any other surviving researchers. Wesker splits the team up to search the mansion. His own team finds the body of a man recently killed by Jill, though Barry is confused by his necrotic flesh which suggests he were dead far longer than his wounds suggest. Meanwhile, Ridley disobeys orders and checks out the kitchen, where the tunnel Chris entered leads. In the confusion, a Zombie security guard is able to maul Ridley from behind. Rebecca hears Chris' gunshot and investigates, but he escapes through another tunnel.
- Chris Redfield - a ranch owner of Mohawk descent.
- S.T.A.R.S. members:
- Jill Valentine - the leader of the S.T.A.R.S. Bravo Team, and Chris' girlfriend.
- DiSimone - a Bravo Team soldier
- Russo - a Bravo Team soldier
- Williams - a Bravo Team soldier
- Albert Wesker - An Army colonel and CO of S.T.A.R.S. He leads Alpha Team into Raccoon City, and has ties to Umbrella.
- Rebecca Chambers - Alpha Team's medic.
- Barry Burton - An Alpha Team member and Gulf War veteran, who has been a friend of Wesker's since childhood.
- Ridley - An Alpha Team member, killed in the kitchen early on.
- Joseph Frost - An Alpha Team member killed by the guard dogs outside the mansion.
- Rosie Rodriguez
- John Marcus - The chief researcher at the Arkley Mansion lab.
- Ada Wong - one of the few surviving researchers during S.T.A.R.S.' investigation, and John's girlfriend.
- The mansion is named after Arkley, an alcoholic beverage bootlegger who built it to use as a safehouse during the Prohibition Era. He was even responsible for the mansion's secret passages.
- Through the script, there is only the use of colorful magnetic card keys in the Arkley Mansion and the lab.
- The S.T.A.R.S. Alpha Team arrives at the Arkley Mansion in the morning.
- Chris is a civilian rancher with no relation to S.T.A.R.S. or the RPD. His involvement in the Mansion Incident happens after his ranch is ravaged by zombie dogs and he goes to investigate the mansion on his own.
- Jill and Chris are romantically involved, but Jill uses this relationship as a cover for her investigation.
- Barry is described as "a muscular black man, as big as a grizzly, with the heart of a Teddy".
- Barry and Wesker are childhood friends.
- Plant 42 roars like a lion, more specifically the MGM's mascot.
- The Hunters are described as "ape-like... and lizard-like... with ferocious eyes that glare from beneath an insect- like carapace...". They are capable of climbing walls and have metal armour grafted onto them beneath a synthetic skin.
- The Yawn is a failed T-Virus experiment on a copperhead snake left to reside in the greenhouse with Plant 42.
- Ada Wong is altruistic, having once believed the research on t-Virus would be beneficial to mankind.
- The Tyrant is encased in a frozen tube. Its exposed heart is an implant from rhinoceros.
- The Arkley Lab explosion also takes down Chris' ranch and Raccoon City, already evacuated but occupied by some zombies.
- Forest Speyer mentions George A. Romero's Night of the Living Dead movie, admitting knowledge about zombie horror fiction.
- The script dialogue often makes jokes about the expression "So... we live here now", Rosie Rodriguez's catchphrase.