Resident Evil Re:Verse features third person over the shoulder multiplayer action with characters from the Resident Evil franchise. Four to six players take part in 5-minute deathmatch battles, using weapons and items found through the map, with the player scoring the most points at the end of the match winning. Each Human character has their own set of skills and weapon loadout.
Humans that are taken down transform into powerful Bioweapons that can change the tide of battle, with players able to upgrade their Bioweapon transformation by obtaining Virus Capsules. Once the Bioweapon is killed, the player will respawn as a Human.