Contrary to Sega's The House of the Dead, and Capcom's Umbrella Chronicles, Resident Evil Survivor is not an on-rails shooter. All movement is based around the wish of the gamer as they walk around the three-dimensional setting.
The game features branching paths that allow the player to determine how the story will unfold and who they will meet along the way.
Resident Evil Survivor is unusual in that it only lets the player save if they die and decide not to continue, or if they beat the game. Saving however only saves items, weapons, ammo, and files, not actual progress.
The handguns and the rocket launcher have infinite ammo, but the Shotgun, Grenade Gun and Magnum have limited ammo that needs to be encountered. The shotgun ammo is the easiest to found and normally the Tyrants drop it when killed. Magnum ammo is rare but powerful. The grenade gun has three different types of ammo: explosive, flammable and acid. To more information, see Grenade Rounds. These weapons need to be encountered, too. The rocket launcher is only unlocked after finishing the game with an S ranking (to get this rank is necessary to play on Normal difficulty, under one hour and a half, without using first aid sprays, making various critical hits and without dying).