(Capcom's primary storyline)
Ryan was one of the Tricell employees who worked in their Uroboros Laboratory in Africa, underneath the former Umbrella Corporation's facility. He and the rest of the research staff are tricked by Tricell and Albert Wesker into thinking that they are given an early vacation period in the celebration of their work. Instead, they are rounded up and killed to prevent security-leaks regarding the Uroboros virus.
- Resident Evil 5 (2009), file: "An E-mail to an aquaintance"
- Resident Evil 5 (2009), file: "Report on Implementation of Preventing Information Leaks"