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Alexander Slater was an Umbrella Corporation Executive, serving as the second in command of Umbrella's Science Division, and, in the wake of the Global T-Virus Outbreak, the North American Research Facility. Although he was supposedly subordinate to Sam Isaacs, in reality he answered directly to Umbrella's Chairman, Albert Wesker. Wesker had hopes that Slater could be a comfortable medium between the loyal incompetence of Timothy Cain and the brilliant ambition of Isaacs. Following a failed attempt by Isaacs to retrieve Alice in the ruins of Las Vegas, Slater executed him on Wesker's orders. But Isaacs had already been infected with an enhanced strain of the T-Virus, and had self-administered large quantities of the Anti-Virus. Isaacs began to mutate, killing Slater with a trio of tentacles, and proceeding to massacre the entire facility staff.

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