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Parks was a security operative who stayed in the mansion in order to protect the identity of the Hive. He married Alice in a marriage that was faked in order to protect their identities. They still had romantic feelings for each other, though. Spence Parks planned to steal a sample of the T-virus and sell it on the black market in order to make he and Alice richer. He did this for Alice and before leaving to do so, he wrote a note to her: "Today, all your dreams will come true." The nerve gas that the Red Queen released caused him to lose his memory.

He intentionally caused the T-virus Outbreak inside The Hive to cover the theft, and in turn, was responsible for the infection of Raccoon City. He was also indirectly responsible for the Global T-virus Outbreak. When James "One" Shade and his commando team entered the Hive, they found him. Alice did support his theft of it, saying that Umbrella should be brought to justice for their illegal experimentation.

After stealing the Anti-Virus, he headed back to the train where he was then killed by the Licker. He then became a Zombie, and was quickly killed (again) by Alice.

He was portrayed by actor James Purefoy.

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