"Reduces damage when guarding. Effects are maximized when paired with "The Essence of Defense.""
— Inventory description
The Secrets of Defense is an unlockable item that appears in Resident Evil 7: Biohazard. The player must complete the game on normal difficulty or higher to unlock it.
After clearing the game once on normal or higher difficulty, the Secrets of Defense will be put in the Item Box on subsequents playthroughs. Like the Essence of Defense, it reduces the damage received when blocking attacks and needs to be in the player's inventory for it to function. It can be paired with the Essence of Defense to maximize its effect.