A week later, Raccoon City was accidentally contaminated by the Corporation's t-Virus, thus forcing Umbrella to deploy Wolfpack into the quarantined area with orders to commence Operation Raccoon City. The failure to contain the outbreak placed Umbrella in a precarious situation for if the world ever learned of their involvement in the destruction of Raccoon City, as well as their research in bio-weaponry, the backlash would almost certainly destroy Umbrella Corporation. To ensure Umbrella's survival, Wolfpack was charged with destroying all evidence that could encriminate the company, including civilians and R.P.D. officers because any survivor was also an eyewitness, and thus a potential threat to Umbrella's existence. At the same time, the U.S. government sent a detachment of armed troops to enforce the quarantine of Raccoon City and to ascertain the nature of Umbrella's involvement in the contamination of the area. As a result, Wolfpack fought and killed numerous American soldiers throughout the course of their mission.
Most of the team members display sadistic tendencies and lack compassion for others, especially the UBCS. In certain instances, they describe them as "guinea pigs", saying how "nobody cares about a few dead UBCS".
Despite this, upon HUNK revealing the UBCS detachment guarding Birkins lab are considered expendable, one of them will remark, "Aren't we on the same team? Couldn't we just pick up the phone?" Additionally, one of the team members will reprimand Nicholai for leaving his team to the zombies.