The Umbrella Africa Laboratory was a top-secret virus research facility constructed by Umbrella Pharmaceuticals in the 1960s. The facility was abandoned by order of CEO Dr. Oswell E. Spencer in 1998, and re-opened years later in secret by Tricell.
The facility was inaugurated during a set of incursions into the underground ruins of the Ndipaya Kingdom. Its purpose was to cultivate plant specimens which were discovered to be a natural source of the Progenitor Virus. Until the late 1980s there was no means of cultivating the plants with the precise conditions to trigger production of the virus, and the facility was therefore the only source of the virus from the 1960s. The facility lasted until 1998 under the directorship of Dr. Brandon Bailey, wherein its researchers were executed along with anyone else who had worked there or had knowledge of it.
The pharmaceutical enterprise, Tricell, under the guidance of Albert Wesker and Excella Gionne, claimed the abandoned facility and began creating their own, further underground. It was here that they further developed the Progenitor Virus and began work on the Uroboros Project. In 2009, the facility was infiltrated by BSAA agents Chris Redfield and Sheva Alomar. They would discover the intentions of Wesker and Gionne as they ventured through the facility. Inside, they found a large revolving elevator, which was surrounded by thousands of capsules housing the test subjects of the Uroboros Project. Also, they encountered numerous creatures including: Licker β, the U-8, Reapers and firearm wielding Majini. They would eventually rescue Jill Valentine from Wesker's control and exit the facility to board the Tanker. Wesker and Excella were soon killed, finally leaving the Umbrella Africa Research Facility closed for good.
To date, the Umbrella Africa Laboratory is one of the few laboratory settings in the series to not feature a self-destruct mechanism, the others being the Uroboros Laboratory and the Caucasus Laboratory.