(Covers information from Anderson's universe)
The Detroit Medical Facility is one of Umbrella's headquarters, presumably located in Detroit, Michigan.
Three weeks after the Raccoon City Incident, Alice was taken to this facility by Dr. Alexander Isaacs to be revived after she was killed while trying to escape Raccoon City. Alice fully recovered but had lost her memory. Shortly afterward, she regained her memory and injured Isaacs, along with several researchers and security guards.
Alice made her way outside the facility, only to be cornered by heavily armed U.S.S. forces. Luckily, Carlos, Jill, and L.J. disguised as Umbrella employees rescued her. Isaacs ordered security to let them go and activates "Program: Alice". It is unknown if this facility is still operational or fell during the Global T-Virus pandemic.