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Umbrella Prime is a top secret underground laboratory in Resident Evil: Retribution, under the command of the reprogrammed Red Queen.
Background
Located off the coast of Russia in submarine pens built in the 1980s, the facility was utilized for the testing of bio weapons in a controlled environment where potential purchasers could witness their destructive power.
The outpost had several replicated environments established inside of it including reasonable facsimilies of several city blocks in Berlin, New York, Moscow, Tokyo, and at the center was a replica of Raccoon City's suburbs. Among its other notable features was a massive cloning chamber that could produce hundreds of clones from the fifty available models and numerous bio weapons. It was eventually flooded by Leon Kennedy's strike team while rescuing Alice.