The Verdugos were created by a fusion of human and insect DNA implanted with Plagas. Two Verdugos, presumably the only two in existence, served as Ramon Salazar's bodyguards. They concealed their mutated forms beneath voluminous Los Iluminados cloaks, with one wearing red and the other wearing black.
When Leon survived a booby trap in The castle, the diminutive master of the castle sent his red-cloaked Verdugo to kill the intruder personally. The Verdugo cornered Leon in the sewers under the castle, but the former Raccoon City Police officer managed to kill it. The black-cloaked Verdugo remained at Salazar's side and eventually fused with its master and the Queen Plaga to fight Leon.